Christel Hydén-Granskog
The Modern Laboratory · People
The Modern Laboratory
Christel Hydén-Granskog
A Helsinki doctor who carried single embryo transfer into frozen embryo cycles, and into the study of the earliest human development.
From genetics to embryos. Christel Hydén-Granskog is a Finnish doctor at the Reproductive Medicine Unit of Helsinki University Hospital. Her first papers, in the early 1990s, mapped the genes behind a rare inherited skin condition in Finnish families. She then turned to reproductive medicine, studying hormone signals in cells from the ovary.
Part of the Helsinki team. She co-wrote the 1999 Family Federation study that opens Room 7. She also co-wrote the 2001 Helsinki paper on single transfer with embryo freezing. In 2005 she led a study of 1,647 frozen embryo transfers at her hospital. Multiple deliveries were 21.9 per cent after two frozen embryos and 2.0 per cent after one. When a single embryo was chosen on purpose, the delivery rate was as good as with two.
Watching the first days. Later work took her into basic science. With colleagues in Helsinki and Stockholm she studied how the genes of a human embryo first switch on. She also studied small RNA molecules in eggs and early embryos. She has also contributed to Nordic surveys of preimplantation genetic testing.
Also see: Sirpa Vilska, Aila Tiitinen, Outi Hovatta
About the sources
- Vuoristo S, Bhagat S, Hydén-Granskog C, et al. DUX4 is a multifunctional factor priming human embryonic genome activation. iScience 2022;25(4):104137. PubMed 35402882, https://pubmed.ncbi.nlm.nih.gov/35402882/
- Paloviita P, Hydén-Granskog C, Yohannes DA, et al., Tuuri T. Small RNA expression and miRNA modification dynamics in human oocytes and early embryos. Genome Research 2021;31(8):1474–1485. PubMed 34340992, https://pubmed.ncbi.nlm.nih.gov/34340992/
- Hreinsson J, Iwarsson E, Hanson C, et al. Preimplantation genetic testing practices in the Nordic countries. Acta Obstetricia et Gynecologica Scandinavica 2020;99(6):707–715. Affiliation for Hydén-Granskog: Reproductive Medicine Unit, Helsinki University Hospital. PubMed 32034767, https://pubmed.ncbi.nlm.nih.gov/32034767/
- Hydén-Granskog C, Unkila-Kallio L, Halttunen M, Tiitinen A. Single embryo transfer is an option in frozen embryo transfer. Human Reproduction 2005;20(10):2935–2938. PubMed 15980000, https://pubmed.ncbi.nlm.nih.gov/15980000/
- Tiitinen A, Halttunen M, Härkki P, Vuoristo P, Hyden-Granskog C. Elective single embryo transfer: the value of cryopreservation. Human Reproduction 2001;16(6):1140–1144. Affiliation: Department of Obstetrics and Gynaecology, Helsinki University Central Hospital. PubMed 11387283, https://pubmed.ncbi.nlm.nih.gov/11387283/
- Vilska S, Tiitinen A, Hydén-Granskog C, Hovatta O. Elective transfer of one embryo results in an acceptable pregnancy rate and eliminates the risk of multiple birth. Human Reproduction 1999;14(9):2392–2395. Affiliation: Infertility Clinic, The Family Federation of Finland, Helsinki. PubMed 10469718, https://pubmed.ncbi.nlm.nih.gov/10469718/
- Liu J, Hydèn-Granskog C, Voutilainen R. Gonadotrophins inhibit and activin induces expression of inhibin/activin beta(B) subunit mRNA in cultured human granulosa-luteal cells. Molecular Human Reproduction 2001;7(4):319–323. PubMed 11279293, https://pubmed.ncbi.nlm.nih.gov/11279293/
- Hydén-Granskog C, Salonen R, von Koskull H. Three Finnish incontinentia pigmenti (IP) families with recombinations with the IP loci at Xq28 and Xp11. Human Genetics 1993;91(2):185–189. PubMed 8096494, https://pubmed.ncbi.nlm.nih.gov/8096494/
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Compiled with AI-assisted research and checked against the original sources. Not yet peer-reviewed. Corrections are warmly welcomed.
