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1980: How it was done

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The Founding Papers · FP·06 · 1980

1980: How it was done

Two years after Louise's birth, Edwards, Steptoe and Purdy set out the whole method for the first time, in twenty pages.

A desiccator that was placed inside an incubator, used in the development of IVF, 1977.
A desiccator that was placed inside an incubator, used in the development of IVF, 1977.Science Museum Group. © The Board of Trustees of the Science Museum. CC BY-NC-SA 4.0.

The story

The team had learnt to follow a woman's own natural cycle. They tested her urine every three hours, day and night, to catch the hormone surge that signals an egg is about to be released. Then Steptoe collected the egg, and the embryo was grown in the laboratory.

They also noticed something remarkable. The four pregnancies in this series all followed embryo transfers made late in the evening.

Jean Purdy is a named author, alongside the two men, on this full account of the work that changed medicine.

“Fertilization and cleavage occurred in 34 instances, and 32 embryos were put into the mother via the cervical canal. Four patients became pregnant.”From the paper's abstract

The paper

Establishing Full-Term Human Pregnancies Using Cleaving Embryos Grown in vitro

Robert Edwards, Patrick Steptoe, Jean Purdy

British Journal of Obstetrics and Gynaecology 1980;87(9):737 to 756. September 1980. Read the paper.

How we know

Abstract from PubMed and Europe PMC, read 6 October 2026. The full text could not be opened.

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